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Low B12 levels have been linked with memory problems and even dementia but studies have not shown any B12 benefit in people with one of these conditions, even in megadoses of 1,000 micrograms

In SURMOUNT-1, nausea occurred in 24.6% of participants on 5mg, 33.3% on 10mg, and 31.0% on 15mg

Persistent inflammation past week 6 on KLOW

Others may take a few weeks to experience consistent benefits as the brain adapts and neuroplasticity improves

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Traditionally, managing these issues has relied on physical therapy, over-the-counter medications like NSAIDs, and time