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(1997) Iron accumulation in Alzheimer disease is a source of redox-generated free radicals

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The significant reduction in caloric intake represents the most direct mechanismwhen energy consumption drops substantially, particularly during the initial treatment phase, the body may not immediately adapt its energy expenditure accordingly

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ROS regulates MAPK and NF-B signaling pathways, further affecting cell proliferation, angiogenesis, and apoptosis in joints (173)