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The main aim is to pick a clean, flat patch of skin and keep the pen steady during the dose

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doi: 10.1016/S2213-2600(18)30427-2 78 SpencerSDonovanTChalmersJDMathioudakisAGMcDonnellMJTsangAet al

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He stated: "Large studies with more dogs from different breeds should be conducted to confirm the results." UPDATE JULY 2023: In a July 2023 article, an international team of veterinary cardiologists and nutritionists tested Purina's Pro Plan CardioCare kibble dog food on a group of 101 MVD-affected dogs, including 29 cavalier King Charles spaniels (29%), all in Stage B1, over a 365 day period to see if it met its claims that it would slow or arrest echocardiographic left heart enlargement in Stage B1 dogs