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We propose that hepatic activation of TH signaling has insulinotropic and glucose-lowering effects, as it is able to increase non-12-OH FXR-antagonistic BA levels through shaping the BA composition by repressing hepatic CYP8B1, thereby enhancing the GLP-1 production via suppressing intestinal FXR signaling

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[3] [12] [13] Clubbing of the digits, a disfigurement of the finger tips or toes (see image) Abnormal pulmonary function test results, with evidence of restriction and impaired gas exchange