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Maintenance and discontinuation SURMOUNT-4, continue vs placebo switch after lead-in to about 20.9% loss: stopping regained about +14% over 52 weeks while continuing lost a further -5.5%

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The cochlea and the round window membrane are visualized under a stereo surgical microscope

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The release of vasoactive intestinal peptide (VIP) and acetylcholine (Ach) by submucosal neurons stimulates the enterocyte and Cl enters by co-transport with sodium and potassium through the basolateral Na + -K + -2Cl channel