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academic.oup.com/jes/article/9/ GLP-1 in addiction medicine: GLP-1 acts on pancreas, gut, kidney, heart and thyroid receptors to activate reward/stress hubs (VTA, NAc, ARC, PFC, hypothalamus)

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This study concluded that the Ipamorelin peptide appeared to exhibit a short half-life of 2 hours, after which the potential action appears to begin to decline

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Historically, it has even been used in clinical settings to treat certain types of beta-blocker overdose due to these properties