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401 In Hfe / mice, treatment with antisense oligonucleotides targeting TMPRSS6 significantly decrease serum transferrin saturation, iron levels, and liver iron accumulation

Lancet 355 , 11791180 (2000)

Iron overload induces M1 polarization, as confirmed by studies showing increased M1 markers, such as IL-6, TNF-, and IL-1, with a concurrent reduction in M2 markers, including tissue transglutaminase 2 (TGM2), effectively promoting M1-type macrophage polarization (97)

Erastin/sorafenib induces cisplatin-resistant non-small cell lung cancer cell ferroptosis through inhibition of the Nrf2/xCT pathway

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