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GLP-2(Tirz) dual GIP/GLP-1 agonism consistently documents 20-22% reductions, validating that GIPR co-activation adds a quantifiably distinct contribution beyond GLP-1R alone not just amplification of the same pathway

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Tran MT, Son GH, Song YJ, Nguyen NT, Park S, Thach TV, Kim J, Sung YW, Das S, Pramanik D (2023) CRISPR-Cas9-based precise engineering of SlHyPRP1 protein towards multi-stress tolerance in tomato

GLP-1 drugs reduce your appetite and can cause a decline in fluid intake