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Conclusion: Is microdosing GLP-1s right for you

64.25 mg sitagliptin monohydrate equivalent to 50 mg sitagliptin and 779.86 mg of metformin equivalent to 1000 mg metformin HCl (JANUMET XR 50/1000)

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When paired with a reduced-calorie diet and regular exercise, research shows that these medications are effective for weight loss clinical trial participants reported a 15-20% reduction in body weight

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Severe insulin resistance / T2D : low doses may be less clinically visible, so the model can push the target upward, but it still builds through the lower adaptation rungs