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[DOI] [PMC free article] [PubMed] [Google Scholar] 86.Pfeffer M.A., Claggett B., Diaz R., Dickstein K., Gerstein H.C., Kber L.V., Lawson F.C., Ping L., Wei X., Lewis E.F., et al

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It is mainly synthesised in the liver and the highest stores are generally found in the skeletal muscles

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(History + Background) IGF-1 DES , or Insulin-like Growth Factor 1 DES(1-3) , is a modified version of IGF-1 a powerful anabolic growth factor that plays a critical role in: Muscle growth Tissue repair Recovery Cellular regeneration It is essentially a truncated form of native IGF-1: 13 amino acids shorter than full-length IGF-1 Lacks the first three N-terminal amino acids (hence the name DES(1-3) ) This structural modification gives IGF-1 DES two unique properties: Greatly increased receptor binding affinity 10x more potent locally vs