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Caffeine Limiting or avoiding caffeine is recommended during weight loss because of the potential diuretic effect of high caffeine intake, the Obesity study authors note

The compound crosses the blood-brain barrier efficiently after oral administration and demonstrates sustained cognitive benefits even after treatment cessation, suggesting true structural enhancement rather than temporary stimulation

Often times these medication side effects go away with longer use of GLP-1s

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Cenas N, Nivinskas H, Anusevicius Z, Sarlauskas J, Lederer F, et al