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Several other studies have also provided evidence that GLP-1RA can reduce hepatic fat accumulation and reduce steatosis in liver tissue by regulating the expression of genes and proteins related to the fat synthesis pathway [109,110]

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Use is contraindicated in individuals with baseline hypoglycemia or conditions predisposing to hypoglycemia

For example, studies using radiolabeled exenatide have shown that it can readily enter the mouse brain, though this central uptake appears to diminish at higher doses (Kastin and Akerstrom, 2003)

Similar results were observed across sensitivity analyses

The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss