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Newer classes of medications, such as glucagon-like peptide-1 (GLP-1) receptor agonists and sodium-glucose co-transporter 2 (SGLT-2) inhibitors, have demonstrated significant efficacy in lowering glycated hemoglobin (HbA1c) levels and reducing body weight [13]

PubMed PMID: 8120456

Underlying hormonal conditions, such as thyroid dysfunction, insulin resistance, or perimenopause, may also slow weight loss

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This work exemplifies how scaffold engineering and ZBG optimization can converge to deliver potent, selective, and pharmacokinetically viable anticancer leads

We work with large employers like the state of Connecticut to really critically think about what would be the best clinical solution for that patient, whether or not its a generic low-cost medication, or a GLP-1 (semaglutide), he said