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As early as the late 1980s, Newsholme and colleagues proposed that the central neurotransmitter 5-HT may serve as a key mediator of central fatigue (Newsholme and Blomstrand, 1995)

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On the other hand, chondrocytes can regulate subchondral bone remodeling through the RANK-RANKL-OPG signaling pathway (Hu Y et al., 2021)

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Members who sign up for the program also can message their clinician outside of scheduled appointments, receive a nutritional guide and recommendations and be guided to an individualized, clinically appropriate treatment program

S.KarouiH.et al (1998)