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Improved moisture retention also supports the skin's barrier against environmental damage

Despite decades of clinical reliance on nucleoside analogues such as acyclovir, the therapeutic landscape has stagnated with rising antiviral resistance, toxicity associated with prolonged use, and the complete inability of current drugs to eliminate latency or prevent reactivation continue to undermine effective disease control

Across trials, the most common side effects are mild digestive issues:4 6 37 Bloating Diarrhea Loose stools Abdominal discomfort Less commonly, skin rashes have been reported.43 Side effects appear dose-dependent

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those with normal glucose tolerance, chemical diabetes (called impaired glucose tolerance), diabetes with minimal fasting hyperglycemia (fasting plasma glucose 140 mg/dL)