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Experiments that have been carried out and resulted in Nrf-2 activation in animals have demonstrated an increase in insulin sensitivity and a reduced chance of developing obesity after a high fat diet (61)

The following practical guidance applies to participants in a clinical trial or approved early-access programme

FIGURE 25-2: Role of carnitine in the transport of long-chain fatty acids through the inner mitochondrial membrane

Both effects are related to the aromatic structure, its resonant electronic configuration, and the ability of the OH to donate a reducing group H + to a free radical, which increases its redox activity

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Patients beginning at lower doses experience shorter, milder nausea episodes compared to those starting at higher doses