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New delivery routes including sublingual, intranasal, and inhaled formulations have attracted patent interest [9, 33, 34] and some scientific attention [35], though market signals remain limited

Receptor-mediated activation of gastric vagal afferents by glucagonlike peptide1 in the rat

No major trials have tested GLP-1s in healthy people with a normal or low BMI, so its unclear how much weight such people might lose on the drug

Sandsdal RM et al

Wegovy gastrointestinal reactions were also most frequently reported during escalation