People who've been managing their weight with weekly injections might soon have a far more convenient option
Extrip Workgroup
Adopting a similar approach might be useful in dogs and cats
Partial reduction of BACE1 improves synaptic plasticity, recent and remote memories in Alzheimers disease transgenic mice
Notably, excessive deposition of ECM within organs leads to the destruction or replacement of parenchymal tissue, irreversible scarring, and organ dysfunction or failure, such as heart failure, chronic renal failure, and chronic pancreatitis (King et al., 2011

(2015) described the development of angiotensin IV analogs including Dihexa and their HGF/c-Met potentiation mechanism (PMID: 25455861) Expression of Concern: The landmark 2012 paper describing Dihexa's cognitive effects received an expression of concern from the journal (PMID: 34551989), citing data integrity issues including questioned Western blot images Retraction: A follow-up paper from the same research group was retracted (PMID: 40312093), further undermining the evidence base for Dihexa's reported effects No Human Studies: No clinical trials, pharmacokinetic studies, or safety assessments have been conducted in humans Limited Independent Replication: The core claims about Dihexa's cognitive-enhancing effects have not been independently replicated by groups outside the original laboratory The Evidence Gap: This comparison starkly illustrates the difference between a compound with decades of clinical validation (Cerebrolysin) and one with provocative preclinical data undermined by integrity concerns (Dihexa)
