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Up until 2017, the only approved SCD treatment was hydroxyurea, despite the disease's high frequency and low survival rates
Nasal administration, on the other hand, works through a completely different mechanism
Running these together produces better outcomes than either alone
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Protein kinase A suppresses sterol regulatory element-binding protein-1C expression via phosphorylation of liver X receptor in the liver
doi: 10.1093/jnci/89.2.166 183 XuYShaoXYaoYXuLChangLJiangZet al
