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Clinical Background BPC-157 was introduced in 1993 and initially studied as a potential treatment for inflammatory bowel disease due to its anti-ulcer effects

Doses above 3 mg per day lack additional evidence of benefit and are not generally recommended

Hirayama, K., Endo, K., Kawamura, S

Elevating NAD+ while inhibiting its methylation loss through NNMT inhibition may enhance mitochondrial biogenesis and oxidative phosphorylation efficiency

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[8] Although not an absolute contraindication, patients with coronary artery disease or unstable angina should only use B-Complex injections containing niacinamide under physician supervision, since high-dose niacin supplements have been linked to arrhythmias in such patients