Am J Respir Crit Care Med 171 : 431439 Fitzpatrick AM, Brown LA, Holguin F, Teague WG, National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program 2009 Levels of nitric oxide oxidation products are increased in the epithelial lining fluid of children with persistent asthma
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found that the abnormal accumulation of double-stranded DNA in the cytoplasm may bind to the cytoplasmic DNA sensor (cGAS), thereby specifically triggering the STING-interferon (IFN) signaling pathway in microglia, promoting the expression and secretion of inflammatory cytokines
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