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A collaborative effort between you and your healthcare provider can lead to the best outcomes

Ironically, a side effect of excessive anticholinesterase treatment is excessive weakness or cholinergic crisis due to excessive stimulation of nicotinic receptors in the muscle end-plate region, resulting in a transient phase of uncontrolled muscle fasciculations due to sustained depolarization, followed by the development of receptor desensitization and a flaccid paralysis

Severe side effects, though rare, can involve gallbladder issues and pancreatitis

Those already using metformin or berberine are generally advised in community sources to consider a lower MOTS-c dose with closer monitoring consult a clinician

The deep tissues and muscles of the esophageal can be affected as the tumour grows