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A 7-fold increase in bioavailability means that a 500 mcg oral dose of the arginate form could deliver the equivalent systemic exposure of approximately 3,500 mcg of the acetate form taken orally

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However, although protracted sensory and motor symptoms may sometimes seem to be almost permanent, they do in fact decline in severity over the years, even without flumazenil, and they do not signify a major neurological illness

An FDA panel voted 8-6 on July 23, 2026 to recommend it for compounding