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In a 72-week study enrolling 3,172 overweight adults, the highest dose of orforglipron (36 mg) caused 12.4% weight loss

Traditionally, Wegovy has been prescribed as a weekly injection

Although the detrimental effect of GLP-1 agonists have remained unclear with suggestions of increased risk of some cancers, recent reports in fact suggest a reduced risk of colorectal cancer (CRC)

The Congressional Budget Office states that there does not appear to be any direct empirical evidence pointing to a medical cost offset

Azzam AY, Essibayi MA, Vaishnav D, et al

Emerging role of SGLT-2 inhibitors for the treatment of obesity