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Dosage varies based on individual needs, but many studies on PCOS and insulin resistance use between 2,000mg and 4,000mg per day

doi:10.2337/dc06-0057

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Participants saw the largest weight reduction when prescribed the maximum dose of tirzepatide (between 10 and 15 milligrams)

Tolerability Issues : The adverse events with the GLP-1-based therapies are primarily gastrointestinal and include nausea, vomiting, constipation, or diarrhea [82], leading to meaningful discontinuation rates that limit real-world effectiveness