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The activity of GPx was significantly reduced in the serum of patients with Keshan disease

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Moreover, a significant proportion of patients exhibit progressive renal decline without prominent albuminuria, resulting in misdiagnosis or delayed detection (Vistisen et al., 2019)

The challenge is that these rules are based on disease treatment, not prevention or optimization

Limitations of Current Evidence The absence of large-scale human clinical trials represents the primary evidence gap

[DOI] [PubMed] [Google Scholar] Zhu Z., Shen J., Wang D., Chen C., Xu Y., Guo H., Kang D., Hamada N., Dong J., Wang G., Liang Y