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The single-molecule architecture allows precisely tuned biased signaling at each receptor, controlling the ratio of cAMP generation to beta-arrestin recruitment in ways that a two-drug combination cannot replicate at matched plasma concentrations

Atkinson, A Trillion-Dollar Opportunity: How Brain Research Can Drive Health and Prosperity (ITIF, July 2016), [141]

Other recent studies suggest that IGF-1 may be regulated by both ER and BRCA1

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GHK-Cu, or glycyl-L-histidyl-L-lysine copper complex, is a naturally occurring copper peptide studied for collagen-related pathways, tissue remodeling, antioxidant defense, and skin repair [7] [8]