Combining the two might theoretically compound these effects, though this has not been formally studied
When phentermine and topiramate were co-administered to rats at doses of 3.75 and 25 mg/kg, respectively [approximately 2 times the maximum recommended human dose (MRHD) based on area under the curve (AUC)], or at the same dose to rabbits (approximately 0.1 times and 1 time, respectively, the clinical exposures at the MRHD based on AUC), there were no drug-related malformations
That general dampening of consumption wasnt a surprise, because this medication is approved already for obesity, for its ability to reduce appetite and food intake, says Leggio, of the National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism in Baltimore
How to Reduce Nausea When Taking Ozempic Practical strategies can significantly reduce nausea and improve tolerability during Ozempic treatment
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