L., Bishop, S
Key outcomes (surgery vs GLP-1 medicines alone) Compared to medications, surgery offers: 32% lower risk of death (all-cause mortality) 35% lower risk of major cardiovascular events (heart attack, heart failure, stroke) 47% lower risk of serious kidney disease 54% lower risk of diabetes-related eye damage (retinopathy) Greater average 10-year weight loss: ~21.6% vs ~6.8% Bigger A1c reduction: 0.86% vs 0.23% Why Surgery Outperformed GLP-1s in the Real World Adherence: Whether or not youre in a study, if you have weight loss surgery, you are left with a permanent tool to help you lose weight and maintain that loss, providing you follow some basic rules
Short-term use (36 months) produces initial weight loss but doesn't address underlying appetite dysregulation
However, the evidence supporting its use remains limited and this device is not yet widely utilized in clinical practice
Bioavailability: Why Formulation Matters If you decide to move forward with glutathione, the most important factor to consider is bioavailability
High levels of circulating melanocyte autoantibodies recognized by T cells specifically against tyrosinase (TRP-1 and TRP-2) have been found in many vitiligo patients with their role being linked to the destruction of keratinocytes and melanocytes (Jimbow et al