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The human results are mixed, with small open-label studies encouraging but the controlled phase 2 OVERTURE trial missing its primary endpoint, and the larger pivotal trial has finished enrolling with results pending, so for now it is best read as mechanistically promising and clinically unproven

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doi: 10.1186/s13601-017-0188-1 [12] Creamer D, Walsh SA, Dziewulski P et al