SCFAs produced by microbiota affect mitochondrial function, for example, the lack of butyrate led to a significant reduction in nicotinamide adenine dinucleotide (NAD), resulting in autophagy in germ-free mouse colon cells [30]
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doi: 10.3389/fmolb.2022.1016090 Received 18 August 2022 Accepted 15 September 2022 Published 29 September 2022 Volume 9 - 2022 Edited by Ye Sun, Boston Children's Hospital, Harvard Medical School, United States Reviewed by Xudong Wang, Massachusetts General Hospital, Harvard Medical School, United States Xiujuan Shi, Tongji University, China Updates Copyright 2022 Ma, Yang, Zuo and Huang