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The point is to let your GLP-1 and GIP receptors begin responding to exogenous stimulation at a pace that does not overwhelm them

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Nature reviews Gastroenterology & hepatology , 9 (11), 633-645

10.1074/jbc.274.20.14147 101

These routes bypass first-pass metabolism, offering more reliable delivery to target tissues, especially in neuroendocrine and immunomodulatory applications

Specifically, it acts as a single peptide that simultaneously activates three receptors involved in metabolic regulation: the glucose-dependent insulinotropic polypeptide receptor (GIPR), the glucagon-like peptide-1 receptor (GLP-1R), and the glucagon receptor (GCGR)