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Thresholds of high permeability were defined by the 95th percentile of all slopes in a previously examined control group

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Ultimately, inflammasome activation and IL-1 production lead to extracellular matrix deposition and kidney fibrosis 91,92

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FIGURE 9 KAR activation appears to be similar to that of AMPARs, likely proceeding via a pre-active state, in which Glu is bound but the ion channel remains closed (Twomey et al., 2017a