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Low-dose PLX5622 treatment prevents neuroinflammatory and neurocognitive sequelae after sepsis

At this stage, the combined inhibitory effect of the dual signals on this neuronal population is significantly more potent than that achieved by GLP-1R mono-agonists

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The risk of gastrointestinal effects appears dose-dependent, with higher doses generally associated with more pronounced symptoms

In the absence of published reports describing synchronized weight loss and CRC management in patients with severe obesity, three novel retrospective case examples were included to demonstrate feasibility during neoadjuvant treatment, with institutional review board approval obtained for all cases