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Nat Rev Cardiol 20(8):560573 [DOI] [PubMed] [Google Scholar] 6.Kang YJ, Park C-S (2025) Mechanisms and management of obstructive sleep apnea: A translational overview
Trends Pharmacol Sci (2017) 38:7634
Dosage Ranges Clinical evidence, on the other hand, suggests that the drug remains effective at low to moderate doses
Further Increases: Depending on the efficacy and tolerability, the dose can be increased to 10 mg once weekly after at least 4 weeks on the 5 mg dose, and potentially to 15 mg once weekly after at least another 4 weeks
Poor glycemic control, hypothyroidism, prior gastric or bariatric surgery, and concurrent use of medications that affect gastric motility (such as opioids, anticholinergics, or cannabis) may also amplify risk