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Apart from diminishing efficiency, degradation can form harmful compounds resulting in delayed treatment, worsening symptoms, or a false sense of security
Chaudhary 2010
Unfortunately, for the same reasons that compounded semaglutide can no longer be manufactured, there is no compounded version of tirzepatide
In the UK, the MHRA has approved specific GLP-1 agonists for different indications
When treatment is titrated toward weight loss rather than glycemic control, average reductions can be much larger, with a trial-level result of 14.9% body weight loss over 68 weeks under a weight-focused escalation protocol
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