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Drug working concentrations and stock preparation were as follows: GLP-1MK-801 and MK-801 (both 50 M, dissolved in aCSF or magnesium-free aCSF), NMDA (100 M, dissolved in magnesium free aCSF), CNQX (10 M, dissolved in DMSO, Alomone Labs), picrotoxin (100 M, dissolved in DMSO)

Semaglutide: Selective GLP-1 receptor agonist

The simplest way to do this is to use a standard concentration, like the 1mg/ml ratio we discussed earlier

Yao H, Zhang A, Li D, et al

Ichiki, T., Dzhoyashvili, N

When released after eating, GLP-1 signals the pancreas to produce insulin, reduces the release of glucagon, slows stomach emptying, and communicates with the brain to increase feelings of fullness