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HGF influenced the metastasis of c-MET-positive cells into multiple organs, including the liver, kidney, lymph nodes, lung, gonads, and the central nervous system, in SCID mice but did not affect metastasis of c-MET-negative lymphoma [15]

As shown in Additional file 1: Fig

This structural modification allows IGF-1 LR3 to circulate unbound and biologically active for 2030 hours, whereas native IGF-1 remains more than 99% bound to IGFBP-3 with a half-life of only 10 minutes