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The Department has expanded the MAPP user slots available to each PPS on multiple occasions since MAPPs inception and continues to accept feedback from PPS regarding use based requests
On the data side, the Lau phase 2 obesity trial showed Cagrilintide monotherapy producing dose-related weight loss, reaching close to 10.8 percent at the top dose over roughly 26 weeks, against about 3 percent on placebo
Guarner-Lans, V
doi: 10.1038/s41598-023-27405-w 75 HaoFTamWHuXTanWJiangLJiangXet al
Tirzepatide is contraindicated in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2, and should not be used during pregnancy due to potential fetal harm
[1] [13] When B12 levels are borderline or clinical suspicion remains high despite normal B12, additional tests include: Holotranscobalamin (active B12) , which may be more sensitive in early or borderline deficiency Methylmalonic acid (MMA) and homocysteine levels, which become elevated in functional B12 deficiency (note that MMA is also elevated in renal impairment, and homocysteine rises in folate and B6 deficiency) Full blood count to identify macrocytic anaemia (elevated mean cell volume) Blood film examination may show hypersegmented neutrophils and megaloblastic changes Serum folate should be checked concurrently, as deficiencies often coexist Investigating the underlying cause is essential for appropriate management
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