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Testing may be appropriate if: Weight loss exceeds 1520% Fatigue, hair thinning or neuropathy develops Persistent vomiting or diarrhoea occurs Dietary intake becomes severely restricted You are in a higher-risk group (e.g., premenopausal women, older adults, GLP-1 + metformin users) Monitoring should be personalised rather than automatic

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To verify that glucagon-stimulated somatostatin secretion does not depend on insulin signalling, we infused glucagon (as above) with continuous addition of S961 (Fig

doi: 10.1007/s11926-018-0710-z 115 NoskovicovaNSchusterRvan PuttenSEzzoMKoehlerABooSet al

Given these factors, patients may require longer to achieve sustainable metabolic adjustments

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