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In vitro experiments using STC-1 cells as enteroendocrine cells demonstrated that ICG-001, a selective inhibitor of Wnt/catenin signaling, dose-dependently reduced proglucagon gene expression

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FB: Conceptualization, Supervision, Writing original draft, Writing review & editing

research into the role of the gut microbiome is at an early stage and is not yet used clinically to guide treatment decisions Adherence to treatment: Missing doses or inconsistent injection timing may reduce efficacy Concurrent medicines: As a class effect, GLP-1 receptor agonists slow gastric emptying, which may affect the absorption timing of some oral medicines

DPP-4 inhibitors (DPP-4i) enhance plasma levels of GLP-1 and several other GI hormones including GIP by inhibiting their degradation

Glucagon-like peptide-1 suppresses advanced glycation end product-induced monocyte chemoattractant protein-1 expression in mesangial cells by reducing advanced glycation end product receptor level