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GLP-1RAs have the potential to inhibit cardiac inflammation via retarding the production of pyroptotic cytokines, caspase-1 and the AMPK-thioredoxin interacting protein (TXNIP) pathway in high-fat diet-fed rats [80]

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Back Randle, PJ (29 May 1954) 'Assay of plasma insulin activity by the rat-diaphragm method', British Medical Journal , 1, 1237-40

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Sin embargo, Morales explica que en la Fase III se ajustar la dosis de titulacin y la dosis final destinada a la comercializacin, lo que permitir optimizar el equilibrio entre eficacia y tolerancia y recuerda que en Espaa tambin tenemos un papel bastante activo y un desarrollo clnico robusto, similar a otros frmacos de la familia de los coagonistas del GLP-1/GIP

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