The preservation of the active site architecture, notably the cysteine residue at position 36 (Cys 36 ), coupled with the marked reduction in enzymatic activity exhibited by the GpoA Cys36Ala variant relative to the wild-type enzyme, provides compelling biochemical support for the essential role of this residue in mediating GpoAs peroxidase function
Incubation of root extracts of A
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doi: 10.1007/s11892-014-0552-7 44 KorposKadriNKappelhoffRWegnerJOverallCMWeberEet al
ALA has anti-oxidant properties and protects against oxidative stress, which may be beneficial given the potential role of mitochondrial dysfunction and neuroinflammation in the pathogenesis of FM [72, 73]
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