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~ AlphaMD Many people associate nicotine primarily with smoking and tobacco use, but with the growing popularity of nicotine gum, patches, and other alternatives, questions arise about how nicotine itself affects the body

And I found this was one of the first articles that Ive read that really pointed out what we do every day in the clinic, which is modifying technique

Cancer Prevention and Longevity Research in animal models suggests DSIP reduces tumor incidence and chromosomal defects ( 10, 12 )

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This doesn't mean expensive always equals better, but it does suggest that formulation expertise matters for tolerability