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As shown in Figure 1 , alterations in the abundance of beneficial intestinal clostridia across different autoimmune diseases are presented

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It has been established that cerebral ischemic injury results in a core of necrotic tissue surrounded by a penumbra of tissue in which neurons are functionally inactive but still potentially viable [9]

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Though pathogenic RFK mutations are rare, animal models have shown that RFK loss results in impaired mitochondrial electron transport, NF-B activation, cognitive decline, and neuroinflammation, highlighting its disease relevance

Cagrilintides most well-known clinical synergy is with semaglutide, where it is being studied as part of a combination therapy to enhance weight loss outcomes