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During protein folding stress, the sirtuin SIRT7 also plays an important role by contributing to repressing nuclear respiratory factor 1 (NRF1) activity, a major transcriptional regulator of mitochondrial genes

As an additional control, we further included a group of GLP-1GIP-treated mice that were additionally food-restricted to match the body weight of the GLP-1GIPLani-treated mice

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