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Even in patients taking these drugs strictly for weight loss, pre-existing but unnoticed motility issues can exist

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In a prespecified analysis of DAPA-CKD, patients with T2DM had a 35.1% reduction in UACR in comparison to 14.8% in nondiabetics suggesting attenuated reduction in intraglomerular hypertension in nondiabetics

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But with elevated health costs and concerns over growing utilization, employers are asking if this trend will continue

It indicates that the drug may have serious side effects or pose a unique risk