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We have a full summary of all the major pre-clinical studies and trials below, but as Reta is in Phase III, it's clear that: It showed significant benefit and low safety risk during pre-clinical trials to justify clinical trials

Furthermore, validation has been achieved with small molecules such as GSK137647A, which activates the Free Fatty Acid Receptor 4 (FFAR4, also known as GPR120), and with Sinigrin, an agonist of the Bitter Taste Receptor 38 (TAS2R38)

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The face is highly vascular, so being precise and cautious is key, she said

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Journal of Diabetes Investigation