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Systemic administration of therapeutics also results in off-target effects, as only a small fraction of the administered dose crosses the BBB, with the remainder accumulating and affecting peripheral tissues 71,72
Swarup, D.H
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Because these agents inhibit transmission in both sympathetic and parasympathetic ganglia, physiological effects reflect blockade of the predominant resting autonomic tone, including tachycardia (cardiac) and marked orthostatic hypotension (vascular) (middle panel)
Catapol attenuates the aseptic inflammatory response to hepatic I/R injury in vivo and in vitro by inhibiting the HMGB1/TLR-4/NF-B signaling pathway via the microRNA-410-3p
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