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IGF-1 LR3 is not appropriate for patients who are pregnant or breastfeeding, have active cancer or a cancer history (because IGF-1 stimulates cell growth broadly, including potentially malignant cells), have uncontrolled diabetes or diabetic retinopathy, or are under 21

It requires significant energy and oxygen to function, which makes it a primary site for the production of reactive oxygen species (ROS)

Hunger often returns once the initial effect fades

Vision Loss (Non-arteritic anterior ischemic optic neuropathy NAION) Suicidal Ideation or attempted suicide linked to the medication

Long-term effects of exenatide therapy over 82 weeks on glycaemic control and weight in over-weight metformin-treated patients with type 2 diabetes mellitus

Muscle tissue is metabolically active, meaning it burns more calories at rest compared to fat tissue